3D organ models—Revolution in pharmacological research?

3D Organ Printing

Engineering a 3D, biological construct: representative research in the South Carolina Project for Organ Biofabrication.

The SC Project is an alliance of 10 colleges and universities working together to achieve the goal of engineering a functional, 3D, bioengineered construct. Scientific progress includes computational modeling of vascular trees and experimental testing of natural and engineered constructs. Future directions of the science focus on overcoming challenges such as scalability, sustainability of biof...

Editorial: In vivo Imaging in Pharmacological Research

The discovery and development of a biologically active molecule with therapeutic properties is an increasingly complex task, highly unpredictable at the early stages and frequently marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very long and costly. The improvement of the net outcome in drug discovery and dev...

Pharmacological models in Alzheimer's disease research

Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reproduce the AD pattern. The few studies that used a combination modeling approach, ...

Use of microdialysis in translational pharmacological research

Kehr Jan*, Takashi Yoshitake, Bengt Dahlström, Folke Sjöberg 1 Pronexus Analytical AB, Grindstuvägen 44, 167 33 Bromma, Sweden. 2 Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, 171 77 Stockholm, Sweden. 3 CTC Clinical Trial Consultants AB, Sveavägen 8, 752 36 Uppsala, Sweden. 4 Department of Clinical and Experimental Medicine, Faculty of Health Sciences, L...